Validation of diagnostic magnetic resonance imaging criteria for multiple sclerosis and response to interferon β1a
Identifieur interne : 00AE69 ( Main/Exploration ); précédent : 00AE68; suivant : 00AE70Validation of diagnostic magnetic resonance imaging criteria for multiple sclerosis and response to interferon β1a
Auteurs : Frederik Barkhof [Pays-Bas] ; Mara Rocca [Italie] ; Gordon Francis [États-Unis] ; Jan-Hein T. M. Van Waesberghe [Pays-Bas] ; Bernard M. J. Uitdehaag [Pays-Bas] ; Otto R. Hommes [Pays-Bas] ; Hans-Peter Hartung [Autriche] ; Luca Durelli [Italie] ; Gilles Edan [France] ; Oscar Fernández [Espagne] ; Pierette Seeldrayers [Belgique] ; Per S Rensen [Danemark] ; Simon Margrie [Australie] ; Marco Rovaris [Italie] ; Giancarlo Comi [Italie] ; Massimo Filippi [Italie]Source :
- Annals of Neurology [ 0364-5134 ] ; 2003-06.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Centre médical, Homme, Neurologie.
English descriptors
- KwdEn :
- Barkhof, Barkhof criteria, Baseline, Beta interferon, Cdms, Chemotherapy, Confidence interval, Criterion, Cumulative number, Cutoff, Diagnosis, Diagnostic criteria, Early treatment, Etoms, Etoms data, Gadolinium, Gadolinium enhancement, Human, Individual barkhof criteria, Infratentorial, Infratentorial lesion, Infratentorial lesions, Interferon, Juxtacortical, Juxtacortical lesions, Lesion, Logistic regression, Magnetic resonance imaging, Mcdonald, Mcdonald criteria, Medical centre, More periventricular lesions, Multiple sclerosis, Neurol, Neurology, Nuclear magnetic resonance imaging, Odds ratio, Periventricular, Placebo, Positive criteria, Predictive value, Sclerosis, Treatment.
- Teeft :
- Barkhof, Barkhof criteria, Baseline, Cdms, Confidence interval, Criterion, Cumulative number, Cutoff, Diagnostic criteria, Early treatment, Etoms, Etoms data, Gadolinium, Gadolinium enhancement, Individual barkhof criteria, Infratentorial, Infratentorial lesion, Infratentorial lesions, Interferon, Juxtacortical, Juxtacortical lesions, Lesion, Logistic regression, Magnetic resonance imaging, Mcdonald, Mcdonald criteria, Medical centre, More periventricular lesions, Multiple sclerosis, Neurol, Neurology, Odds ratio, Periventricular, Placebo, Positive criteria, Predictive value, Sclerosis.
Abstract
In the recently proposed diagnostic criteria for multiple sclerosis (MS) by McDonald, the modified magnetic resonance imaging (MRI) Barkhof criteria have been incorporated. We examined the validity of this implementation in the Early Treatment of MS study, a randomized, double‐blind, placebo‐controlled study of 22μg interferon β1a given subcutaneously once weekly in 309 patients with a first episode consistent with demyelinating disease (and abnormal MRI). Conversion to clinically definite MS (CDMS) within 2 years of follow‐up, as evidenced by a new clinical episode, occurred in 41% of patients (independent of treatment) with gadolinium enhancement or nine or more T2 lesions versus 11% of those without either finding (p = 0.017); similarly, proportions converting were 44% versus 31% for infratentorial lesions (p = 0.026), 40% versus 35% for juxtacortical lesions (p = 0.413), and 41% versus 17% for three or more periventricular lesions (p = 0.034). The rate of conversion to CDMS based on the number of modified Barkhof criteria was 22% for two or fewer positive criteria, increasing to 47% with four positive criteria. For a cutoff of three positive criteria, the hazard ratio for time to CDMS was 2.3 (95% confidence interval, 1.17–4.55; p = 0.016). Treatment effect seemed more evident as the number of positive criteria increased, and the number of patients needed to avoid one patient converting to CDMS decreased from 50 in patients with one or two positive criteria to 5.6 in patients with four positive criteria. However, the study was not powered to detect statistically significant treatment by variable interaction, and this remains an important issue for further study.Ann Neurol 2003;53:718–724
Url:
DOI: 10.1002/ana.10551
Affiliations:
- Australie, Autriche, Belgique, Danemark, Espagne, France, Italie, Pays-Bas, États-Unis
- Gueldre, Hollande-Septentrionale, Hovedstaden, Lombardie, Massachusetts, Nouvelle-Galles du Sud, Piémont, Région Bretagne, Région de Bruxelles-Capitale
- Amsterdam, Bruxelles, Copenhague, Milan, Nimègue, Rennes, Sydney, Turin
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Le document en format XML
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Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Filippi, Massimo" sort="Filippi, Massimo" uniqKey="Filippi M" first="Massimo" last="Filippi">Massimo Filippi</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Neuroimaging Research Unit, Department of Neuroscience, IRCCS San Raffaele, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Annals of Neurology</title><title level="j" type="alt">ANNALS OF NEUROLOGY</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><biblScope unit="vol">53</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="718">718</biblScope><biblScope unit="page" to="724">724</biblScope><biblScope unit="page-count">7</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-06">2003-06</date></imprint><idno type="ISSN">0364-5134</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Barkhof</term><term>Barkhof criteria</term><term>Baseline</term><term>Beta interferon</term><term>Cdms</term><term>Chemotherapy</term><term>Confidence interval</term><term>Criterion</term><term>Cumulative number</term><term>Cutoff</term><term>Diagnosis</term><term>Diagnostic criteria</term><term>Early treatment</term><term>Etoms</term><term>Etoms data</term><term>Gadolinium</term><term>Gadolinium enhancement</term><term>Human</term><term>Individual barkhof criteria</term><term>Infratentorial</term><term>Infratentorial lesion</term><term>Infratentorial lesions</term><term>Interferon</term><term>Juxtacortical</term><term>Juxtacortical lesions</term><term>Lesion</term><term>Logistic regression</term><term>Magnetic resonance imaging</term><term>Mcdonald</term><term>Mcdonald criteria</term><term>Medical centre</term><term>More periventricular lesions</term><term>Multiple sclerosis</term><term>Neurol</term><term>Neurology</term><term>Nuclear magnetic resonance imaging</term><term>Odds ratio</term><term>Periventricular</term><term>Placebo</term><term>Positive criteria</term><term>Predictive value</term><term>Sclerosis</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chimiothérapie</term><term>Diagnostic</term><term>Homme</term><term>Imagerie RMN</term><term>Interféron bêta</term><term>Sclérose en plaques</term><term>Traitement</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Barkhof</term><term>Barkhof criteria</term><term>Baseline</term><term>Cdms</term><term>Confidence interval</term><term>Criterion</term><term>Cumulative number</term><term>Cutoff</term><term>Diagnostic criteria</term><term>Early treatment</term><term>Etoms</term><term>Etoms data</term><term>Gadolinium</term><term>Gadolinium enhancement</term><term>Individual barkhof criteria</term><term>Infratentorial</term><term>Infratentorial lesion</term><term>Infratentorial lesions</term><term>Interferon</term><term>Juxtacortical</term><term>Juxtacortical lesions</term><term>Lesion</term><term>Logistic regression</term><term>Magnetic resonance imaging</term><term>Mcdonald</term><term>Mcdonald criteria</term><term>Medical centre</term><term>More periventricular lesions</term><term>Multiple sclerosis</term><term>Neurol</term><term>Neurology</term><term>Odds ratio</term><term>Periventricular</term><term>Placebo</term><term>Positive criteria</term><term>Predictive value</term><term>Sclerosis</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Centre médical</term><term>Homme</term><term>Neurologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the recently proposed diagnostic criteria for multiple sclerosis (MS) by McDonald, the modified magnetic resonance imaging (MRI) Barkhof criteria have been incorporated. We examined the validity of this implementation in the Early Treatment of MS study, a randomized, double‐blind, placebo‐controlled study of 22μg interferon β1a given subcutaneously once weekly in 309 patients with a first episode consistent with demyelinating disease (and abnormal MRI). Conversion to clinically definite MS (CDMS) within 2 years of follow‐up, as evidenced by a new clinical episode, occurred in 41% of patients (independent of treatment) with gadolinium enhancement or nine or more T2 lesions versus 11% of those without either finding (p = 0.017); similarly, proportions converting were 44% versus 31% for infratentorial lesions (p = 0.026), 40% versus 35% for juxtacortical lesions (p = 0.413), and 41% versus 17% for three or more periventricular lesions (p = 0.034). The rate of conversion to CDMS based on the number of modified Barkhof criteria was 22% for two or fewer positive criteria, increasing to 47% with four positive criteria. For a cutoff of three positive criteria, the hazard ratio for time to CDMS was 2.3 (95% confidence interval, 1.17–4.55; p = 0.016). Treatment effect seemed more evident as the number of positive criteria increased, and the number of patients needed to avoid one patient converting to CDMS decreased from 50 in patients with one or two positive criteria to 5.6 in patients with four positive criteria. However, the study was not powered to detect statistically significant treatment by variable interaction, and this remains an important issue for further study.Ann Neurol 2003;53:718–724</div></front></TEI><affiliations><list><country><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Gueldre</li><li>Hollande-Septentrionale</li><li>Hovedstaden</li><li>Lombardie</li><li>Massachusetts</li><li>Nouvelle-Galles du Sud</li><li>Piémont</li><li>Région Bretagne</li><li>Région de Bruxelles-Capitale</li></region><settlement><li>Amsterdam</li><li>Bruxelles</li><li>Copenhague</li><li>Milan</li><li>Nimègue</li><li>Rennes</li><li>Sydney</li><li>Turin</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Barkhof, Frederik" sort="Barkhof, Frederik" uniqKey="Barkhof F" first="Frederik" last="Barkhof">Frederik Barkhof</name></region><name sortKey="Barkhof, Frederik" sort="Barkhof, Frederik" uniqKey="Barkhof F" first="Frederik" last="Barkhof">Frederik Barkhof</name><name sortKey="Barkhof, Frederik" sort="Barkhof, Frederik" uniqKey="Barkhof F" first="Frederik" last="Barkhof">Frederik Barkhof</name><name sortKey="Hommes, Otto R" sort="Hommes, Otto R" uniqKey="Hommes O" first="Otto R." last="Hommes">Otto R. Hommes</name><name sortKey="Uitdehaag, Bernard M J" sort="Uitdehaag, Bernard M J" uniqKey="Uitdehaag B" first="Bernard M. J." last="Uitdehaag">Bernard M. J. Uitdehaag</name><name sortKey="Van Waesberghe, Jan Ein T M" sort="Van Waesberghe, Jan Ein T M" uniqKey="Van Waesberghe J" first="Jan-Hein T. M." last="Van Waesberghe">Jan-Hein T. M. Van Waesberghe</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Rocca, Mara" sort="Rocca, Mara" uniqKey="Rocca M" first="Mara" last="Rocca">Mara Rocca</name></region><name sortKey="Comi, Giancarlo" sort="Comi, Giancarlo" uniqKey="Comi G" first="Giancarlo" last="Comi">Giancarlo Comi</name><name sortKey="Durelli, Luca" sort="Durelli, Luca" uniqKey="Durelli L" first="Luca" last="Durelli">Luca Durelli</name><name sortKey="Filippi, Massimo" sort="Filippi, Massimo" uniqKey="Filippi M" first="Massimo" last="Filippi">Massimo Filippi</name><name sortKey="Rovaris, Marco" sort="Rovaris, Marco" uniqKey="Rovaris M" first="Marco" last="Rovaris">Marco Rovaris</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Francis, Gordon" sort="Francis, Gordon" uniqKey="Francis G" first="Gordon" last="Francis">Gordon Francis</name></region></country><country name="Autriche"><noRegion><name sortKey="Hartung, Hans Eter" sort="Hartung, Hans Eter" uniqKey="Hartung H" first="Hans-Peter" last="Hartung">Hans-Peter Hartung</name></noRegion></country><country name="France"><region name="Région Bretagne"><name sortKey="Edan, Gilles" sort="Edan, Gilles" uniqKey="Edan G" first="Gilles" last="Edan">Gilles Edan</name></region></country><country name="Espagne"><noRegion><name sortKey="Fernandez, Oscar" sort="Fernandez, Oscar" uniqKey="Fernandez O" first="Oscar" last="Fernández">Oscar Fernández</name></noRegion></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Seeldrayers, Pierette" sort="Seeldrayers, Pierette" uniqKey="Seeldrayers P" first="Pierette" last="Seeldrayers">Pierette Seeldrayers</name></region></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="S Rensen, Per" sort="S Rensen, Per" uniqKey="S Rensen P" first="Per" last="S Rensen">Per S Rensen</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Margrie, Simon" sort="Margrie, Simon" uniqKey="Margrie S" first="Simon" last="Margrie">Simon Margrie</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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